4 edition of Redox-active metals in neurological disorders found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Steven M. LeVine, James R. Connor, and Hyman M. Schipper.|
|Series||Annals of the New York Academy of Sciences -- v. 1012.|
|Contributions||LeVine, Steven M., Connor, James R., Schipper, Hyman M., 1954-|
|LC Classifications||Q11 .N5 vol. 1012, RC347.5 .N5 vol. 1012|
|The Physical Object|
|Pagination||x, 358 p. :|
|Number of Pages||358|
|ISBN 10||1573315028, 1573315036|
|LC Control Number||2004001532|
Redox-Active Metals: Iron, Copper, and Zinc. As neurological disorders are of multi-factorial origin, oxidative stress requires considerable attention as one of the confirmed components, making it a key therapeutic target in combating these neurological disorders. The recent challenges of adverse effects and failed clinical trials, due to Cited by: 7. Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.
published a number of papers in the Diagnosis and treatment of neurological smell and taste disorders. He is the author of the Neurology Now and AAN publication in of the book entitled “Navigating Taste and Smell Disorders”. This book is very user friendly and written for patients, caregivers and all health care Size: 1MB. Neurological diseases and disorders are those that affect the brain, including Parkinson’s Disease and Alzheimer’s Disease. Environmental factors are suspected of playing a large role in both the onset and severity of both diseases, in addition to genetics, aging, and other factors.
While metals have been implicated in multiple pathologies, including cancer, neurotoxicity is believed to be their most common manifestation. Compelling evidence has etiologically linked abnormal brain metal accumulations with aging, as well as various neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Wilson’s Cited by: Some of these mechanisms have the potential to be protective in some situations and potentiaIly damaging in others. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process. This seetion ends with a chapter on antioxidant therapeutic strate gies in neurological disorders.
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Redox-Active Metals in Neurological Disorders (Annals of the New York Academy of Sciences) [Levine, Steven M., Connor, James R., Schipper, Hyman M.] on *FREE* shipping on qualifying offers. Redox-Active Metals in Neurological Disorders (Annals of the New York Academy of Sciences).
Redox-active metals in neurological disorders. New York, N.Y.: New York Academy of Sciences, (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Steven M LeVine; James R Connor; Hyman M Schipper.
Redox‐Active Metals in Neurological Disorders: Annals of the New York Academy of Sciences: VolNo 1. Skip to Main Content. Search withinThis JournalNYAS PublicationsWiley Online Library. Search term. Advanced SearchCitation Search. Search term. Advanced SearchCitation Search. Search term.
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In contrast to the nonspecific nature of oxidative damage, redox signaling involves specific oxidation/reduction reactions that regulate a myriad of neurological processes such as neurotransmission, homeostasis, and by: 6.
Redox-Active Metals in Neurological Disorders 作者: Levine, Steven M. (EDT)/ Connor, James R. (EDT)/ Schipper, Hyman M. (EDT) 出版社: New York Academy of Sciences 页数: 定价: 装帧: HRD ISBN: Redox-active metals have been implicated in the pathogenesis of numerous neurological disorders.
Redox-active metals catalyze reactions that are essential for normal nervous system function, but they also participate in the generation of toxic free-rad.
Abstract: Considerable evidence is mounting that dyshomeostasis of the redox‐active biometals, Cu and Fe, and oxidative stress contribute to the neuropathology of Alzheimer's disease (AD).
Present data. redox-act ive metals, the m ost physi ologically r elevant of which are iron and cop per. These. metal s are essential for the transport, storage, and activ ation of O.
2., and for electron. Metals and Oxidative Damage in Neurological Disorders. Editors (view affiliations) James R. Connor The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely.
This seetion ends with a chapter on. One of them is the book entitled Redox-Active Metals in Neurological Disorders (Annals of the New York Academy of Sciences) By.
This book gives the reader new knowledge and experience. This book gives the reader new knowledge and experience. A number of studies performed on biological systems have shown that redox-active metals such as iron and copper as well as other transition metals can undergo redox cycling reactions and produce reactive free radicals termed also reactive oxygen species (ROS) or reactive nitrogen species (RNS).
The most representative examples of ROS and RNS are the superoxide anion radical and nitric oxide Cited by: About this book This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in.
While redox-active iron (Fe) and copper (Cu) undergo redox-cycling reactions, for a second group of redox-inactive metals such as arsenic (As) and cadmium (Cd), the primary route for their.
The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic lateral sclerosis has been intensively studied. However, the origin of these disorders remains uncertain.
This review article critically describes the physiology of redox metals that produce oxidative stress, which in turn leads to cascades of immunomodulatory alteration of neurons in multiple sclerosis and amyotrophic lateral by: Redox active metals may undergo cycling reactions participating in the transfer of electrons between metals and substrates and therefore may play an important role in the maintenance of redox homeostasis, a phenomenon tightly linked with metal homeostasis (Lindeque et al., ).Cited by: Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies.
It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future. Formulation samples with no metal chelator have shown that redox-active metal ions, such as ferrous (Fe +2), cuprous (Cu +2) and manganese (Mn +2) ions, account for approximately 1 ppm of trace metals in Biologic A drug product.
It was obvious that trace metal analysis is inconclusive in determining the amounts of trace metals if their. Redox-active metals in the brain mediate numerous biochemical processes and are also implicated in a number of neurodegenerative diseases. A number of different approaches are available for quantitatively measuring the spatial distribution of biometals at an image resolution approaching the subcellular level.
Measured biometal levels obtained using laser ablation-inductively coupled plasma Cited by: Indeed, metal accumulation in brain triggers different kinds of metal-promoted damages related to neurodegeneration: those caused by the presence of redox-active metals, such as copper and iron, leading to reactive oxygen species (ROS) and oxidative stress responsible for severe neuronal damage, and those that involve protein modification, misfolding, and aggregation.
17 These phenomena are Author: Erika Ferrari. Several marine-derived compounds have shown potential in the treatment of neurological disorders.
The Special Issue "Marine Compounds and Its Application in Neurological Disorders" aims to present recent advances in the discovery and development of marine natural products, which can affect the nervous system or have therapeutic potential.This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases.
Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology.Title: Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease VOLUME: 8 ISSUE: 7 Author(s):Lawrence M.
Sayre, Mark A. Smith and George Perry Affiliation:Departments of Chemistry Case Western Reserve University, Cleveland, OHUSA Keywords:Oxidative Stress, Neurodegenerative, Disease, Alzheimer disease, Parkinson disease (PD), amyotrophic lateral .